Last post https://celpeggy.wordpress.com/2014/09/20/my-co-1686-6th-month/ I reported that the Relief Onc (RO) in the absence of my Onc’s Onc, raised my Metformin dosage from 1000mg daily to 2000mg daily all because my glucose reading that morning was 190 compared to 117 three weeks before.
Prior to the dosage change, a little discussion had ensued.
My husband said to RO, “Maybe we should see first how the glucose numbers go before adding 1000mg.”
“Yes, we can do that,” replied RO.
“No, let’s raise it now,” my number one advocate insisted adamantly. That would be me. I wanted the big-dose Metformin handy in case the glucose numbers shot up uncotrollably like what some trial participants experience, according to the boards.
“Yes. You want to do that? Let’s do it right now,” said RO.
RO was the agreeable kind of guy. I bet he votes “yes” to all municipal bond issues during elections.
That same day, Tuesday, I started on the Metformin 2000mg per day.
The loss of appetite caused by the initial Metformin 1000mg had just barely disappeared when the additional 1000mg carpet-bombed my system. Suddenly the Metformin 2000mg megadose side effects were like a grizzly bear mauling my body, tossing me around like a rag doll! Diarrhea got me strategizing restroom coordinates. Fortunately, as a Tarceva Diva, my Big D GPS expertise is still intact. The more worrisome side effect was the nausea and appetite loss. I didn’t like that at all. I want to wake up each morning looking forward to medium rare prime rib and slabs of sashimi and beer. But no! I had to shove food down my throat just to get nutrition. So Tuesday, Wednesday, and Thursday, I went along with the 2000mg program. By Friday morning, it became clear the clinical trial’s “royalties” needed to talk. The dethroned Queen of Zero Side Effects emailed the Lord of Lung Cancer(LLC).
Following is the actual transcript. Asterisked name protects the innocent.
SUBJECT: FEELING LIKE CACA
Last Tuesday while my fasting glucose was 190, I felt great. Dr. RO* followed the protocol and raised the Metformin another 1000mg inasmuch as my kidney numbers are good.
Since the 2000mg Metformin, I have not felt well. I’ve had the mother of all post-nasal drips that caused me to nauseate, lose all appetite, and my right ear to pop. Maybe the nausea is not just from the post-nasal drip.
My glucose last night before bedtime was 126; fasting glucose this morning 123. Two hours after a meal of protein bar, a plum, a fourth of a banana, and milk toast, the glucose was 226.
Could the Metformin 2000mg be just too much for this dainty little old chick?
Thank you very much.
Usually metformin causes tummy upset – so nausea could be from this – it wont be the cause of the nose or ear issues though.
Glucose numbers are good on it though.
Are you taking it in AM or PM and 2000 all at once or 1000 twice a day?
1000 twice a day
Lets try an experiment
Take it once a day for a few days and see if you feel better. If so then cautiously reintroduce and see if you feel the same
Did I understand it?
2000 once a day?
Nope 1000mg once a day (ie drop back to what you did before and see if you feel better – as not sure if metformin or some other bug you have)
END OF CONVERSATION
Per LLC’s advice I went back to 1000mg per day, this time all at once in the morning. The effect of the dosage reduction was incredibly immediate. The post-nasal drip abated and my appetite rose from the dead. My husband claimed that I appeared to have felt better right after my contact with the Good Doctor. Of course the contact made me happy because it meant the dosage reduction would be with his blessing. On my own, I have ideas about dosages. But I’m a clinical trial participant, and being a Data Dame – my more glamorous term for trial guinea pig – I have a responsibility to be true to the trial.
I am faithfully recording my glucose readings at crack of dawn and at the end of day and proving so far that the additional 1000mg Metformin is totally an overdose.
Which reminds me, 15 years ago, after suspecting I might have diabetes and reading so much about it, I dabbled on glucose measurements. It was not in me to see a doctor. Just for kicks, I bought a glucose testing thingy along with the strips and the lancets then conducted my own private clinical trials! I took glucose measurements at different times – before eating, after eating, before workouts, after workouts, etc. I’d wolf down a huge slice of cheesecake, then run to my Nordic Trac machine and exercise like crazy. I noticed glucose numbers did go down after physical exercise.
Back to my last visit at the trial site, I believe my husband and I were right that the glucose high but within-normal-range number that morning was due to two days of inactivity. I wonder why the agreeable Dr. RO did not say “yes” to that. Nobody’s perfect, I guess.
So everything is fine so far. Next trial site visit is October 7th. Let’s see what the Good Doctor does to the additional 1000mg of Metformin that we yanked out temporarily.
As the world turns……